As the group grows older and subsequent infections take place, antibodies to additional families of virus are acquired. The antibody of childhood is largely a response to вЂ¦ the virus causing the first Type A influenza infection of the lifetime. He noted that, regardless of whatever influenza A strains were in circulation, subjects tended to have dominant antibody responses to the strains that were current in their early childhood: Original Antigenic Sin was most influentially described by Thomas Francis in 1960. These antibodies bind to multiple epitopes on the virus particles, and in the process they give the slower-moving naive B-cells little chance to learn about any new, mutant virus features. When a slightly mutated form of the virus arrives, these memory B-cells begin pouring forth the antibodies they learned to produce during the first infection. Forever after, they specialise in producing antibodies against those specific antigens. These B cells then become either memory B cells or plasma cells. When a virus infects your body for the first time, your naive memory B cells imprint on specific virus proteins, or antigens, presented to them. The mechanisms of Original Antigenic Sin are not fully understood, but we have a rough idea of what might be happening. Despite multiple reinfections across the whole population, we are never quite immune to the flu, because its strategy is to exploit the way our immune systems learn. It is the primary reason that respiratory viruses like influenza return again and again. This is not a crazy internet fantasy, but a well-observed limitation of human immunity. The Public Health England data provide powerful reasons to suspect that the vaccines may be compromising immunity to SARS-2 via Original Antigenic Sin. In such systems, it is very unlikely that any effect can be put down to a single cause. Our vaccines reduced the average virulence of SARS-2, and the virus adapted to reattain the prior, optimal balance.Д«ut the virus and its interactions with human hosts constitute a complex system. Certain Delta sub-strains, previously punished for their excessive aggression in unvaccinated populations, have likely been favoured by the vaccines, which reduce symptoms in the vaccinated without preventing infection for more than a few months. We might imagine that all viruses have an optimal level of population-wide virulence вЂ“ an advantageous degree of aggression at which they can spread effectively, while not driving their hosts underground too soon. First, there seems to be a Marek Effect at work. IвЂ™ve explored a few different possibilities. The most pressing question has become, simply: What is going on? While the vaccinated appear to enjoy some protection against severe outcomes, skyrocketing transmission means most countries have seen little benefit, on balance, from their universal vaccination campaigns. Instead, case statistics have ballooned almost everywhere. This unprecedented campaign has not eradicated Corona it has not even suppressed infections. Nearly 7 billion doses have been administered worldwide.

To review: We have now had ten months of mass vaccination against SARS-CoV-2.

Looking is the original sin